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Mitochondrial DNA is maternally inherited, so shouldn't patterns of mitochondrial inheritance and expression parallel that of X-linked genes? Why or why not?

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No, the patterns of inheritance and expr...

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Mitochondrial and nuclear DNA differ in density, permitting separation with density gradient centrifugation. What is the source of this density difference?

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The AT:GC ratio of mitochondri...

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The endosymbiotic hypothesis of mitochondrial origins suggests that modern-day mitochondria are descended from symbiotic bacteria, in particular an ancestral member of the purple nonsulfur photosynthetic bacterial group. How can evolutionary biologists be so specific as to group of origin? What kinds of analyses would help narrow down the possibilities, leading biologists to this group?

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DNA sequence data for both coding and no...

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Extranuclear inheritance refers to genes located in


A) the nucleus.
B) the chloroplasts.
C) the mitochondria.
D) A, B, and C
E) B and C only

F) B) and D)
G) A) and B)

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In the maternal effect case of shell coiling in Limnaea snails, a Mendelian cross starting with a dextral (D/D) female and a sinistral (d/d) male yields ________ F2s.


A) all dextral
B) a 3:1 dextral:sinistral ratio
C) all sinistral
D) half dextral and half sinistral
E) None of the above

F) A) and C)
G) D) and E)

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The endosymbiont theory posits that


A) chloroplasts are descended from photosynthetic bacteria.
B) Eukaryotic cells originally lacked mitochondria and chloroplasts.
C) mitochondria originated by free-living bacteria.
D) All of the above
E) None of the above

F) A) and B)
G) B) and E)

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Maternal inheritance is also referred to as maternal effect.

A) True
B) False

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The neutral petites genotype of Saccaromyces would be lethal were it not for


A) nuclear-encoded and cytoplasmically localized fermentation.
B) mitochondrion-independence in yeast.
C) the genes of the chloroplast genome.
D) compensating mutations elsewhere in the genome.
E) all of the above.

F) C) and D)
G) All of the above

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Male sterility stemming from mtDNA mutation is termed


A) mitochondrial male sterility, or MMS.
B) extranuclear male sterility, or EMS.
C) mitochondrial emasculation, or ME.
D) cytoplasmic male sterility, or CMS.
E) mutational male sterility, or MMS.

F) B) and C)
G) A) and D)

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Lateral gene transfers between organellar and nuclear genomes appear to be very common. For example, an approximately 270-kb segment of Arabidopsis mitochondrial DNA is found in the nuclear genome of the plant (Lin et al. 1999. Nature 402: 761-768), and a 33-kb piece of chloroplast DNA is found on chromosome 10 in rice plants (Yuan et al. 2002. Mol. Genet. Genomics 267: 713-720). How do you suppose that DNA sequestered in organelles can be transferred to and integrated with nuclear DNA?

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DNA fragments are likely shuttled betwee...

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The endosymbiosis theory was proposed by Lynn Margulis in the 1980s. Her ideas met with much criticism early on, but ultimately prevailed. Margulis' arguments are a good example of using strong inference, making sense of multiple independent observations with a single explanatory hypothesis. In other words, in this way of investigating nature, seemingly independent observations present a pattern that can be used to deduce process. What are the seemingly independent observations of organellar DNA that make sense in light of the endosymbiosis explanation?

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The size, shape, physical stru...

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Chloroplasts are found in plant and some protist cells, while mitochondria are found in


A) animal cells.
B) plant and fungal cells.
C) animal, plant, protist, and fungal cells.
D) animal and plant cells.
E) animal and bacterial cells.

F) A) and D)
G) C) and D)

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Which of the following is lacking from animal mtDNA?


A) Complete stop codons
B) Histone proteins
C) Introns
D) Ribosomal protein genes
E) All of the above

F) B) and C)
G) B) and D)

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Briefly explain how selective antibiotics can be used to investigate cytoplasmic vs. mitochondrial protein synthesis.

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This chapter explained how mitochondrial...

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List some features of mitochondrial DNA that make these molecules so useful for population studies.

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They are uniparentally inherited and do ...

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The genetic code is universal, including organisms of all kingdoms and organellar DNA.

A) True
B) False

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A patrilineal analog of mitochondrial inheritance is


A) X-linked genes.
B) chloroplasts.
C) the Y chromosome.
D) A, B, and C
E) B and C only

F) C) and E)
G) C) and D)

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Organellar DNA is typically


A) single stranded and linear.
B) single stranded and circular.
C) double stranded and circular.
D) double stranded and linear.
E) None of the above

F) A) and B)
G) C) and D)

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Describe the pattern of inheritance you would expect if you crossed petite yeast mutants with wild-type (grande) individuals, if (a) the petite mutant is mitochondrial, or (b) the petite mutant is nuclear.

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With respect to mitochondrial-mutant pet...

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Which of the following is not a characteristic of non-Mendelian inheritance?


A) The results of reciprocal crosses involving extranuclear genes are not the same as reciprocal crosses involving nuclear genes.
B) Non-Mendelian inheritance is unaffected by substituting a nucleus with a different genotype.
C) Extranuclear genes cannot be mapped to the chromosomes in the nucleus.
D) Extranuclear inheritance is always maternal.
E) Ratios typical of Mendelian segregation are not found.

F) A) and D)
G) B) and C)

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