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In large genomes, MOST reciprocal translocations occur in:


A) coding DNA.
B) noncoding DNA.
C) open reading frames.
D) closed reading frames.
E) inversion regions.

F) A) and C)
G) C) and E)

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Imagine that a researcher is studying a mouse that carries a mutation in Pax7a gene that is involved in muscle development. To his surprise, these Pax7 mutant mice appear relatively normal. What is a possible explanation for this?


A) Other members of the Pax gene family have redundant functions in muscle development (and can compensate for the Pax7 mutation) .
B) The normal copy of Pax7 on the corresponding homologous chromosome is sufficient for mouse survival.
C) These Pax7 mutant mice may have a synonymous mutation.
D) All of these choices are correct.

E) B) and C)
F) A) and C)

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_____ mutations are important to the evolutionary process; most cancers result from _____ mutations.


A) Somatic; germ-line
B) Germ-line; somatic
C) Germ-line; heritable
D) Somatic; heritable
E) Point; germ-line

F) All of the above
G) A) and D)

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A chromosomal mutation where a segment breaks off, flips, and then reattaches itself is called a(n) :


A) inversion.
B) duplication.
C) translocation.
D) deletion.
E) reciprocal translocation.

F) B) and E)
G) A) and B)

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In organisms with large genomes, inversions are more likely to be tolerated if the breakpoints occur in:


A) coding DNA.
B) noncoding DNA.
C) open reading frames.
D) closed reading frames.
E) reciprocal translocations.

F) A) and B)
G) B) and E)

Correct Answer

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